Principal Associate Scientist -Scientist - Immunology

ContactsBackPrincipal Associate Scientist -Scientist - Immunology Berkeley, CA Contract Apply NowPrincipal Associate Scientist / Scientist - Immunology (Donor Biology)Company Overview:Prellis Biologics is a dynamic startup revolutionizing immunology. We develop cutting-edge technologies to unlock the immune system's potential and drive innovation in therapeutic development.Position Overview:We're seeking an enthusiastic and talented immunologist to play a pivotal role in advancing our groundbreaking ex vivo immune system platform. You'll collaborate closely with a multidisciplinary team to develop innovative lymph node organoids, design and execute impactful in vitro assays, and contribute your expertise to in vitro immune process development and antigen/antibody biomolecular engineering.Responsibilities:Work collaboratively across teams to illuminate the role of human blood donor biology on the responsiveness in Prellis’ ex vivo immunization systemIndependently analyze and evaluate data including but not limited to immunological population dynamics, mRNA seq data, BCR sequence data, TCR sequence data, as well as monoclonal antibody characteristics to identify human blood donors with high potential of success in Prellis’ ex vivo immunization system.Lead human donor blood purchasing, inventory, experimental assignment, and data collection efforts.Establish and employ novel techniques to characterize immune cell responses.Leverage your knowledge in immunology, cell biology, and molecular biology to contribute intellectually to the development of ex vivo immune processes, antibody responses and to facilitate donor selection.Support ex vivo cell culture workflows on occasion.Be hands-on in the lab (60-80% of the time) and thrive in a fast-paced environment.Qualifications:PhD in immunology, cell biology, or a closely related field with 1+ years of relevant industry and/or postdoc experience. MSc in immunology, cell biology, or a closely related field with 4+ years of relevant industry experience.Deep knowledge of adaptive immunology, in particular B and T cell biology and cell-cell interactions.Strong understanding of antibody discovery workflowsExpertise in experimental design, data analysis, and interpreting complex immunological data sets.Extensive immunology lab experience, including flow cytometry (panel design, data acquisition, analysis, troubleshooting).Proficiency in primary cell isolation and culture, and in vitro assay development/execution.Skills & Experience (Preferred):Knowledge of immune tolerance, vaccine development, and systems immunology.Project management expertise.Experience with bioinformatic analysis of proteins and sequences.Familiarity with molecular biology techniques.Experience developing and implementing laboratory systems.Proficiency in FlowJo, and GraphPad Prism software.About Prellis BiologicsAt Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture,...