Executive Director, Global Commercialization Effectiveness

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

This is a rare and highly visible opportunity to help build something new at a pivotal moment in Revolution Medicines' growth. We are seeking an experienced and highly collaborative Executive Director, Global Commercialization Effectiveness to play a foundational role in establishing and scaling commercialization effectiveness as a core capability within the Global Commercialization organization.

This role sits within the newly formed Commercialization Effectiveness & Operations (CE&O) function and will be accountable for commercialization operations, project management, organizational effectiveness, and cross-functional integration across the commercialization organization.

You will partner closely with Global Commercial Leads, Global Medical Leads, Global Market Access Leads, regional leadership teams, and other cross-functional stakeholders to drive alignment, execution, and organizational effectiveness across a diverse portfolio of global commercialization priorities. You will define and continuously evolve the Global Commercialization operating model, ensuring effective integration across Commercial, Medical Affairs, Market Access, and regional organizations while enabling the company's long-term commercialization strategy. The role will establish scalable frameworks, planning processes, governance structures, and organizational capabilities that strengthen execution and support future growth.

Operating in a build-while-scaling environment, this leader will help shape how complex, cross-functional work gets done - bringing clarity, structure, and momentum while partnering closely with senior leaders across the organization. As the capability matures, this leader will build and lead a multidisciplinary organization spanning commercialization operations, project management, governance, planning, and organizational effectiveness.

What You’ll Do

• Serve as the primary integration leader across Global Commercial, Global Medical Affairs, Global Market Access, Regional Commercial Operations, and key corporate functions to ensure aligned planning, prioritization, and execution.

• Define and evolve the Global Commercialization operating model, establishing scalable frameworks that enable execution excellence and organizational effectiveness.

• Provide project management leadership and oversight for Global Commercialization Teams and Global Commercial Teams, ensuring alignment, accountability, and progress across strategic priorities through scalable project management capabilities and teams.

• Maintain overall accountability for execution across a portfolio of high-priority global commercial and commercialization initiatives, ensuring milestones, risks, dependencies, and decisions are effectively managed through appropriate governance, operating processes, and team leadership.

• Manage commercialization governance and planning processes, ensuring effective prioritization, resource allocation, decision-making, and escalation pathways across the commercialization organization.

• Build and scale commercialization effectiveness capabilities, including project management, operations, governance, planning, tools, dashboards, and performance management processes.

• Provide direct operational support to Global Commercial and Market Access organizations, ensuring efficient planning cycles, operational discipline, and execution consistency.

• Lead change adoption efforts related to new tools, processes, and ways of working, ensuring sustainable implementation across a global organization.

• Recruit, develop, and lead a high-performing team, creating scalable capabilities and ways of working that support the future needs of the organization.

Who You Are

You are energized by building infrastructure in ambiguous and rapidly evolving environments. You think in systems and excel at creating clarity, structure, and alignment across complex organizations. You bring a pragmatic, solutions-oriented mindset and are equally comfortable defining strategy and rolling up your sleeves to implement it.

You are a strong collaborator who can influence across functions, regions, and levels of the organization, and you communicate with clarity from operational teams through executive leadership. you're excited to help shape how a global commercialization organization operates by building the infrastructure, capabilities, and ways of working that enable both outstanding execution today and continued growth over time.

Required Skills, Experience and Education:

• Bachelor's degree with 12+ years of relevant experience in biotech, pharmaceutical or healthcare industry, including significant experience leading complex commercial or commercialization initiatives.

• Experience supporting global commercialization organizations, including involvement in launch readiness, operational planning, or capability buildout.

• Experience working across global and regional operating models, with demonstrated ability to drive alignment across geographies.

• Demonstrated Executive Director-level capability, including defining operating models, building scalable organizational capabilities, and driving cross-functional alignment in evolving organizations.

• Strong operational leadership skills, including process design, governance, performance management, and cross-functional coordination.

• Proven success partnering with senior commercial, medical, and access leaders to enable organizational effectiveness.

• Experience building and scaling high-performing teams and organizational capabilities.

• Track record of thriving in ambiguous, fast-moving environments with a hands-on, builder mindset.

• Exceptional communication and interpersonal skills, with the ability to translate complexity into clear and actionable frameworks.

• Strong systems thinking, judgment, and a continuous improvement mindset.

Preferred Skills:

• Advanced degree (MBA/MS/PhD).

• Oncology / specialty pharma commercialization experience.

• Experience building and leading commercialization operations, PMO, organizational effectiveness, or business operations functions.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range$252,000—$315,000 USD

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