Senior Associate Scientist, Chemistry

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/ Senior Associate Scientist I/II, Chemistry RayzeBio is a dynamic biotechnology company headquartered in San Diego, California, United States. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival for people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals. Summary RayzeBio is looking for a Senior Associate Scientist I/II, to support in the development of novel therapeutics in preclinical stages. Candidates will work as part of a team of scientists to synthesize and design both small molecules and peptide analogs to optimize potency, pharmacokinetics, and in vivo efficacy of potential drug candidates. This position offers a challenging and rewarding work environment within a thriving company. Job Responsibilities: Essential duties and responsibilities include the following. Other duties may be assigned. * Executing multi-step synthetic routes, optimizing reaction conditions, isolation, and characterization of organic compounds (chromatography, NMR, MS, IR spectroscopy). * Collaborating effectively with colleagues across diverse disciplines. * Documenting research activities and presenting findings clearly. * Execute experimental plans, troubleshoot synthetic challenges and contribute to the optimization of lead compounds. Education and Experience * BS or MS in Chemistry with strong demonstrable expertise in synthetic organic and medicinal chemistry * 3+ years experience (BS) 2+ years (MS) in a non-academic synthetic chemistry laboratory. Skills and Qualifications * Strong small molecule synthetic skills and knowledge of laboratory techniques and safety, with experience synthesizing peptides a plus. * Proficiency in compound synthesis techniques, reactions, compound purification, troubleshooting and characterization using methods such as LCMS, HPLC and NMR. * Familiarity with scientific software such as ChemDraw, Scifinder, and Reaxys. * Adaptable and flexible, able to handle multiple demands and shifting priorities. * Self-motivated with good interpersonal skills and ability to work effectively in a fast-paced, collaborative environment. * Adept in documenting and presenting findings clearly through laboratory notebook, reports, and presentations. * Uses AI tools to enhance individual productivity and quality of work Physical Demands While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 40 pounds. Specific vision abilities required by this job include close vision and distance vision....